Enjoying a
long life
but, above all,
free of ailments
has become the golden dream of those who, beyond longevity, aspire to squeeze their years without (too many) physical and mental limitations.
In this race to discover the 'potion' that, beyond adding decades, helps us to do so by slowing down the logical
consequences of the passage of time
, several laboratories have spent decades investigating the role that scientists such as Lee Rubin, professor of Regenerative Medicine at Harvard University (United States) and co-director of the Neuroscience Program at the Stem Cell Institute, has not hesitated to call it the
'magic protein'.
What is that 'magic protein' that could become the key to our (almost) eternal youth?
The truth is that his nickname is much more poetic and revealing than his real name because his name is
GDF11
.
"The GDF11 protein belongs to the group of the transforming growth factor beta
'superfamily'
, which regulates the expression of HOX genes, which are fundamental for the regulation of the identity of positional (anteroposterior) changes during
development and growth
", details Vicente Mera, head of the Genomic Medicine and Healthy Aging Unit at SHA Wellness Clinic and Best European Doctor in the field of Antiaging Medicine at the European Awards of Medicine.
It is one of the, according to those who know about this, tens of thousands of proteins that the human body has, what makes it, then, different from the rest?
Is it true that, according to various investigations, it
could help us rejuvenate the brain and muscles
(including the heart) in a much closer future than we think?
Mera tries to explain it to us (and it is not an easy task): "In the classic experiments carried out, in the middle of the last century, by Clive McCay at Cornell University, it was first verified that
caloric restriction
was the only action that
prolonged the longevity
and
youthful physical appearance
of certain mice, which was later confirmed by a pioneering protocol called
parabiosis
(laboratory technique to study physiology by
combining two living organisms
, in this case a young mouse with an old one, which are surgically joined to develop a unique and shared physiological system) that, after a certain time,
the most mature rejuvenated
;
but also that
young people aged prematurely
."
Thanks to, it must be said, this disturbing technique (which is so reminiscent of Dr. Frankenstein's experiments, really), it was observed that "the
brain
, especially the hippocampus, and the
muscles
- indeed, including the heart -
were the organs that showed the most striking changes
. And, these
positive changes
were not only anatomical, but also functional, as highlighted by memory tests."
Mera reports that, more recently, at Stanford University, "they have been able to isolate and purify at least
one protein responsible for what McCay called rejuvenation factors
and that today correspond to
cytokines
(small proteins that play a crucial role in in the control, growth, and activity of other cells of the immune system and blood cells) from stem cells passing through the circulation in
mice in parabiosis
."
As has been verified, continues Mera, "the GDF11 protein is isolated only in the blood of young mice. In mature mice, for its part, it has been seen that, over time,
certain mechanisms are blocked - which would return to function with the protein GDF11 - which prevents stem cells from repairing muscle.
Of course, he emphasizes, "by
injecting the GDF11 protein in old mice
, similar improvements
have been obtained , but of lesser intensity
than those achieved in the experiments with parabiosis, which suggests that there are still more factors to be identified and that they block or stimulate stem cells".
It is known that several laboratories have been working for decades on a formula that allows it to be marketed, but what is the truth in all this?
"The protein is
available on the pharmaceutical market in vials for IV injection for research use only
, but there are already websites that offer the possibility of participating in a randomized study to demonstrate the benefits (and toxicity) of GDF11."
In order to participate in these projects, warns Dr. Mera, "it is necessary to 'donate' a modest amount of money that can reach up to
500,000 dollars
. In such a way that a treatment protocol with GDF11 protein is within the reach of very Few yet."
Conclusion?
"It is clear that sooner or later,
more proteins responsible for aging and rejuvenation will end up being identified
that, without toxicity, are capable of mimicking the effect of parabiosis and can be used to prevent, prolong longevity and improve quality of life. , especially in patients with diseases such as Alzheimer's", concludes this doctor.
Hopefully his omen comes true soon!
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