Start here? Also "disappear" from here?

Will the market completely disappear? The main building will not be demolished

Beginning on March 2, the South China market was deserted after the closure of the market, and construction workers came to Xinhua Road one after another to block the market. On the afternoon of March 3, the staff stationed by the Propaganda Department of Jianghan District Party Committee confirmed that the comprehensive and thorough disinfection work in the market will be completed before March 5. Earlier, there was news that "the South China market will completely disappear." The staff member responded: "Hoards on the premises will be disposed of. Of course, the main building will not be demolished."

At about 5 pm on March 3, the cover journalist followed a group of killing staff to enter Fifteenth Street in the Western District to see that the market was cold and humid, and the emergency power supply was used, and the light was dim.

A killer who wishes to remain anonymous revealed that several disinfections have been carried out since the market closed. This time, it is necessary to enter the interior of the shop for deep killing to prepare for the hoarding of supplies. The light in the market is poor, and some shops have small lofts, and it is necessary for the killers to climb up the stairs or simple ladders before killing them. "The site is slippery, so be careful when going up and down the ladder."

The killer said that according to the killing plan formulated on February 25, when the market materials are cleared and shipped out of the market, the complete disinfection operation of the materials is also responsible for the killing teams. After all the supplies are cleared and transported, the market will conduct a final killing operation, and then perform on-site sample collection and inspection.

On January 26, according to CCTV, the China CDC Virus Institute detected for the first time from 585 environmental samples in the South China seafood market that 33 samples contained the novel coronavirus nucleic acid, and successfully isolated the virus in positive environmental specimens, suggesting that The virus originated from wild animals sold in the South China Seafood Market. The positive samples were distributed in 22 stalls and 1 garbage truck in the market, of which 31 positive specimens were distributed in the western part of the South China Seafood Market, accounting for 93.9% of all positive specimens.

Earlier, a survey by the Wuhan market supervision department found that although the South China Seafood Market was nominally a seafood market, it was actually a comprehensive market. There are wildlife trades in the western part of the market, especially the seventh and eighth streets in the western area, which are close to the interior of the market, and there are many wildlife dealers.

The cover news reporter noted that China CDC test data showed that there were 14 positive specimens near the 7th Street and 8th Street in the Western District, which accounted for 42.4% of all positive samples.

On February 28, Geneva time, WHO held a conference on New Coronary Pneumonia in Geneva.

Maria Van Kokhov, technical director of the WHO Health Emergency Program, said that some of the initial cases in December last year were related to the South China seafood market, but others did not have contact with the market. The pangolin may be an intermediate host, but details are unclear.

Michael Ryan, director of the WHO Health Emergency Program, also said that the appearance of coronavirus somewhere was an unfortunate event in natural history. "We need to know the source of the virus in order to control it and prevent it from coming again, instead of blaming who, or what kind of poor animal's fault, the animal is not wrong."

Not the only source of epidemic? May come in from elsewhere

"My first contact with patients with new coronary pneumonia occurred on December 29 last year when I was consulted at the Integrated Traditional Chinese and Western Medicine Hospital of Hubei Province." On March 2, 39 days after the infection with new coronary pneumonia, I returned to my first post at work, Jinyintan, Wuhan. Huang Chaolin, the deputy director of the hospital, told the cover reporter that at that time, because of his experience in infectious diseases, he was more vigilant.

In addition to the post of Deputy Dean, Huang Chaolin also has an identity as an expert in the Hubei Medical Group. On January 24, Huang Chaolin and others published an online paper through the medical journal "The Lancet" and showed that out of 41 cases, only 27 cases had a history of seafood market exposure. This paper also reminded that there was no history of seafood market exposure in the first patient with disease on December 1, 2019.

The dissertation of Huang Chaolin and others, and the investigation information released by the Wuhan Municipal Health and Health Commission and other departments, are different.

On December 30, 2019, the Medical Affairs Office of the Wuhan Municipal Health and Health Commission notified the district health and health bureaus and affiliated medical institutions to "examine unexplained reasons for having recently visited or worked near the South China Seafood Market. Patients with pneumonia. " On January 5, 2020, the Shanghai Public Health Clinical Center submitted the "Etiology Investigation Report on Unexplained Fever and Pneumonia of South China Seafood Market in Wuhan, Hubei Province" to the National Health and Medical Commission, and the First Edition of Wuhan Health and Medical Commission "Unknown cause of viral pneumonia diagnosis and treatment plan," the South China Seafood Market is regarded as the new crown pneumonia epidemic source, and has become "the target of public criticism."

However, over time, including in front-line hospitals and scientific research institutes, many researchers have swarmed up to carry out traceability research on the source of the epidemic, which has continuously deepened the research on the source of new crown pneumonia. Among them, the South China seafood market "is not the only place of epidemic", one after another, thus making "where is the epidemic place" even more confusing.

Among them, it was directly suggested that "South China Seafood Market is not the birthplace of the epidemic", and it was Yu Wenbin, associate researcher of the Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences (on February 22, the cover news reported it).

The research results were published on the official website of the Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences on February 20. The director of the park's office, Yin Shouhua, responded to the cover news with a text message: "The paper is in a preprinted state, and its research results are awaiting review by peer experts."

According to the paper, researchers collected genomic data on 93 new coronavirus samples from 12 databases on four continents in an open database. Based on 120 mutations, 58 haplotypes (genotypes) were obtained from the South China Seafood Market. Patient sample haplotypes were related to H1, while samples of older genes, H3, H13, and H38, came from outside the South China seafood market. It can be seen that the new coronavirus in the South China seafood market was introduced from other places and spread rapidly outside the market.

Immediately after the publication of this paper by Associate Researcher Yu Wenbin as the first author, there was a speculation that there may be multiple epidemic origins of the new crown virus. Yang Zhanqiu, deputy director of the Institute of Virology of Wuhan University's Medical Department, said that the new crown virus may have multiple origins in the same period, possibly from different animals, different people or different regions, which will help to find the source of the virus and the epidemic prevention and control zone. Come more challenges.

Michael Ryan, the head of the WHO Health Emergency Program, said in Geneva on February 28 that the source of any disease is possible anywhere. Coronavirus is a global phenomenon and exists worldwide.

"It's important that we don't blame its geographical origin, but focus on how to deal with and contain the virus."

Where is "Patient Zero"? Neglected Small Clinic

The source of the epidemic is confusing. Who are the "patients 0" and "patients 1" of the new crown pneumonia? It is still a fog.

"Patient zero" refers to the first person to become infected and start spreading the virus. In epidemiological investigations, patient zero is also referred to as the first case, labeled case. However, this person who carries the virus may not be sick. Therefore, there is also the "patient No. 1" statement, which marks the first patient to develop symptoms. The two are not necessarily equal, and they are often not the same person. In them, epidemiologists can find important indications and provide guidance for subsequent prevention and treatment.

Where can I find "Patient Zero" or "Patient No. 1"? Many epidemiologists' tips: go to the hospital to find cases of fever patients.

Geographically, the South China Seafood Market is not only special, but also has many hospitals around it. At the same time, it is also close to Hankou Railway Station, which sends 5.5 million passengers in the 40 days of the 2019 Spring Festival.

About 500 meters south from the South China Seafood Market, it is the Wuhan Center for Disease Control and Prevention. The center is responsible for emergency treatment of public health emergencies, disease prevention and control, epidemic report and information management in Wuhan.

Opposite Wuhan Center for Disease Control is the Cancer Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. After the outbreak, it has been identified as the designated hospital for critically ill patients with new coronary pneumonia.

Less than 100 meters west, it is Wuhan Youfu Hospital. This is a secondary general hospital. According to public information, on December 12, 2019, a patient with fever and dry cough was admitted here, or the earliest group of patients with new coronary pneumonia in Wuhan.

Taking the South China Seafood Market as the center and expanding the line of sight, the cover news reporter found that 2.3 kilometers to the east is the Houhu District of Wuhan Central Hospital, 1.6 kilometers to the southeast is Wuhan Red Cross Hospital and 1.9 kilometers to the south Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine. The above three hospitals are currently the main battlefields for the treatment of critically ill patients with new coronary pneumonia.

At the same time, there are several large and small old and new communities around the South China Seafood Market. However, according to a number of market operators, most of the market operators rent in the old quarters that are separated by a wall from the eastern district.

The residents introduced that there was a long-term infection in the residents here. The Wuhan Zhongsheng Comprehensive Clinic on the right side of the gate of the community, or one of the earliest consultation clinics. The clinic was closed before the city was closed in Wuhan, and a notice posted on the glass door said: "Interior decoration, business suspension for 15 days."

According to the duty staff who sank the community, the clinic doctors were also infected. The cover news reporter dialed the contact information of the investor Xu surname in the clinic, and the voice prompt showed that the mobile phone number had activated the communication assistant's missed call reminder, and no one was temporarily answering.

Can New Patients with "Zero No. 0" and "Patient No. 1" of New Coronary Pneumonia Be Found? Professor Wang Liming of Zhejiang University's Institute of Life Sciences has certified Weibo and said, "In terms of the new crown pneumonia epidemic, I am quite pessimistic about finding the so-called zero patient."