The meeting took place in Barcelona at the Camp Nou stadium and ended with a score of 5: 2.
As part of the blue garnet, Lionel Messi scored a double (one goal from the penalty spot), Ousmane Dembele, Antoine Griezmann and Pedri also distinguished themselves.
Arnaldo Antonio Sanabria and Lauren Moron scored for the guests.
At the same time, Messi did not play from the first minutes, but came on as a substitute at the beginning of the second half.
In the 60th minute, Betis remained in the minority after Aissa Mandi was sent off.
Barcelona scored 11 points and is in eighth place in the championship standings.
Betis with 12 points is on the seventh line.
Earlier, Atletico forward Luis Suarez said whether he is in contact with Messi.