The meeting at the Gazprom Arena stadium ended with a score of 8:0 in favor of Sergei Semak's wards.
A hat-trick was scored by Wendel (3rd minute, 43rd, 68th), Malcolm scored a double (29th, 59th), Ivan Sergeev (17th) and Daler Kuzyaev (19th ).
The own goal was recorded by the defender of "Orenburg" Alexander Pavlovets (51st).
Zenit is in first place in the Russian Football Championship table with 23 points.
"Orenburg" (nine) is located on the 12th place.
Earlier, Zenit repeated its personal record for the number of goals per match in the RPL.