The meeting, held at the Stade de la Mosson in Montpellier, ended with a score of 3:2 in favor of the hosts.
Elye Vai and Stefi Mavididi (double) distinguished themselves among the winners.
The guests scored Wissam Ben Yedder and Wanderson.
Monegasque Russian midfielder Alexander Golovin missed the match due to an injury.
Monaco have 33 points and are in sixth place in the standings.
Montpellier scored 31 points and is in tenth place.
Earlier, Lokomotiv announced the transfer of Monaco football player Isidore.