The meeting took place in Granada and ended in favor of the hosts - 2: 0.
As part of the Spanish team, Yanhel Herrera and Kenedy distinguished themselves in the 19th and 21st minutes.
The return leg will take place on February 25 in Naples.
Earlier it was reported that Ajax scored two goals in the last minutes and snatched a victory over Lille in the 1/16 finals of the LE.