Kristianstad already visited Uppsala ready for relegation on Sunday and needed a point to secure games in Europe.
Uppsala started well the first ten minutes, before the guests took over the match.
But it took until the 40th minute before the first goal came through Eveliina Summanen, assisted by Hailie Mace.
Therese Åsland then managed to make it 2-0 before the first half was over.
Up in a second place
There were also two quick goals in the second half.
Anna Welin extended the lead to 3-0 in the 51st minute and six minutes later she scored her second goal of the evening and Mace her second assist.
Uppsala got a consolation goal in the 81st minute and the match ended 4-1.
The victory for Kristianstad means that they are ready for games in the Champions League for the 2021/2022 season.
It is the first time in the club's history that they will play in Europe.
They are currently in second place, one point ahead of Rosengård, who, however, has one match less played.