The match, which took place at the "Ludogorets-Arena" stadium, ended with the victory of the guests with a score of 3: 1.
Harry Kane, Lucas Moura and Giovanni Lo Celso scored in the Londoners.
The only goal from the hosts was scored by Claudio Kesheru.
Tottenham have six points after three rounds and are in second place in Group J. Ludogorets did not score a single point and are in last place in the quartet.
Earlier, CSKA's rivals in the Europa League announced coronavirus outbreaks in the teams.