San Francisco won 13 of 16 games in the regular series and, with the first place in its conference, gets the advantage of home ground until the Super Bowl, which will be decided in Miami on February 2.
In the second conference, the Baltimore Ravens had already secured first place. The team ended the baseline series by defeating the Pittsburgh Steelers by 28-10, which was Baltimore's 14th win in 16 games.
Reigning champion New England Patriots are third-ranked in the same conference, opening the NFL playoffs at home against the Tennessee Titans.