The British House of Commons overwhelmingly rejected the EU exit agreement, which was a defeat for Prime Minister Teresa Mae and would bring Britain, the fifth-largest economic power, into the "unknown."
A total of 432 deputies voted against the Brixett, against the support of 202 deputies, while the leader of the opposition British Labor Party, Jeremy Corbin, proposed a motion to withdraw confidence from the government.
The vote is the culmination of more than two years of debate within Britain after the result of the 2016 referendum, the result that most pro-EU MPs found difficult to accept.
In a last-ditch effort to salvage Britain's plan to get Britain out of the EU in about five decades, May told MPs that they should be forced to apply what the British voted for in the 2016 referendum.
"I think it is incumbent upon us to implement the democratic decision of the British people," she warned, warning MPs that the EU would not offer an "alternative agreement".
"The responsibility of each of us at this time is very great, because it is a historic decision that will determine the future of our country for generations."
The opposition to the accord forced Mai to postpone the vote in December in the hope of getting concessions from Brussels.
The EU leaders have provided only a series of clarifications, but German Foreign Minister Haikou Mas hinted at the possibility of further talks in Strasbourg, although he ruled out renegotiating the agreement.