A train collided with a bus at Blaustein near Ulm.
At least three people were injured, a police spokesman said on Tuesday.
The bus crossed a level crossing in the Arnegg district in the morning when the barriers were down, it said.
The regional train was no longer able to brake in time and collided with the bus.
According to information from the SWR, the bus caught fire after the collision and burned out completely.
The accident happened around 8.30 a.m. in the Blaustein district of Arnegg near the B28.
The route is currently closed.