What do you know about the "Angelina Jolie Jane" that threatens men's lives?

 News reports said that a harmful genetic mutation that has long been linked to breast and ovarian cancer in women, or as it is called "the Angelina Jolie gene", leads to an increased risk of prostate cancer in men.

Angelina Jolie became famous for undergoing a preventive mastectomy in 2013 after it was discovered that she had inherited the BRCA1 mutation, which made the mutation bear the name "Jane Jolie".

BRCA1 and BRCA2 are genes that appear naturally in the breast and other tissue cells, and both produce proteins to help repair damaged DNA, or destroy the cell itself if the DNA is not repairable.

Each person carries two copies of each, inherited from both parents.

And when it mutates or becomes defective, it can lead to an increased risk of cancer, Russia Today reported, citing Metro.

Mutations in the BRCA genes are notorious for the risks they pose to women, increasing their chances of developing breast and ovarian cancer.

Now, a new study has provided the strongest evidence to date of links involving BRCA1 or BRCA2 mutations to prostate cancer in men.

The findings could help those at higher risk access cancer screening early.

According to the Cambridge University-led study, men who carry a BRCA2 mutation have a 27 percent increased risk of developing prostate cancer by the time they reach the age of 80.

This is more than double the rate compared to men of the same age who do not carry the genetic mutation.

In both men and women, carrying a BRCA1 or BRCA2 mutation increases the risk of pancreatic cancer by 2.5 percent to 3 percent by age 80.

These genetic defects have also been linked to an increased risk of stomach cancer, although experts have said this type of cancer is very rare.

According to the study, published in the Journal of Clinical Oncology, mutations in both genes significantly increased the risk of developing breast cancer in men, but the disease is still very rare, as breast cancer represents less than 1% of all male cancer cases in the Kingdom. United.

However, the BRCA2 mutation in particular raised men's odds of developing breast cancer 44 times by age 80.

This means that 38 out of every 1,000 males with a BRCA2 mutation will develop breast cancer by the age of 80.

Professor Mark Tishkowitz from the University of Cambridge's Department of Medical Genetics said: 'The link between BRCA2 and prostate and pancreatic cancer is now more clear, thanks to the data we analyzed.

We have also identified a possible association with stomach cancer, but this is based on small numbers and needs further study."

"Overall, the results will add to our knowledge of improving cancer screening strategies and early detection of people known to carry these faulty genes."

The study notes that BRCA mutations are uncommon, affecting about 1 in 300 to 400 people in the population.

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