"100 ○ ○ Immunoomics Project" announced the latest results
new "aging clock" can detect the risk of disease in time
Science and Technology Daily, Beijing, July 12th (Reporter Zhang Mengran) According to the latest research published on the 12th in the British journal Nature Aging, scientists have used artificial intelligence to develop a new "aging clock"-iAge, which provides for all mankind In order to discover new ways of increasing the risk of cardiovascular disease and other diseases in time, and to predict individuals whose risk of disease will increase.
This tool uses blood-based signals that can induce chronic inflammation throughout the body, which is of great significance for early diagnosis and early intervention.
Although the interaction between the immune system and many age-related diseases has been well characterized, there are few immune indicators that can be used to predict who is most at risk.
The goal of the "1000 Immunoomics Project" is to study how the characteristics of chronic inflammation throughout the body change as we age.
As part of this project, researcher David Forman and his colleagues at the Buck Institute for Aging in California, USA, studied blood samples of 1,001 people (aged 8 to 96; 66% were women).
The research team used artificial intelligence to develop a new immune index and called this inflammatory "aging clock" iAge.
The "clock" is based on the concept that the levels of specific immune cells and proteins in the blood fluctuate with aging; but for some people, this fluctuation occurs early, which is also defined as their iAge.
The research team found that the larger the iAge, the earlier this age-related systemic inflammation pattern appears, and it is also more likely to experience various long-term health problems, including decreased immune function, cardiovascular disease, or early physical weakness. .
The researchers also discovered that the chemokine CXCL9 is a protein that usually helps the immune system activate T cells, and its age-related release is also considered a key factor produced by endothelial cells that can accelerate the iAge clock.
The chemokine CXCL9 produces the above effects by promoting cell senescence. During this process, cells are induced into a dysfunctional state, which affects the normal function of blood vessels.
Researchers believe that the iAge "clock" provides a new way to discover the risk of age-related diseases and decreased immune function in individuals, and proposed that CXCL9 and other iAge proteins are potential new targets for the treatment of these symptoms.
Editor-in-chief
iAge, a name full of the breath of the times, you can think of intelligence and electronics, and the cutting-edge of technology when you see it. However, it has nothing to do with the "apple", it has something to do with the aging of the human body. This kind of human body clock provides a new way to detect the increased risk of cardiovascular disease and other diseases in time. Detecting new immune indicators in the blood and deriving the iAge value can also estimate the time and probability of an individual's age-related chronic disease. Some people will face old age earlier, while others will be favored by the God of Time. But knowing the aging clock is not enough. If it can delay the aging process, set the human body clock down, and make related diseases appear later, iAge's research results will be even more cool.