Wang Lin (pseudonym) has been very troubled recently. She gained 20 pounds "for no reason" in two weeks. What puzzled Wang Lin was that her recent diet and life were not special, and she was not pregnant. Wang Lin's increasing weight almost collapsed. In order to find out the reason, Wang Lin went to the Endocrinology Department of Jinan Central Hospital for treatment.
After Wang Lin was hospitalized, the doctor first gave her a general examination. The results showed that Wang Lin's blood pressure was normal, and her liver function, kidney function, blood routine, blood lipids, blood sugar, uric acid, and thyroid function were all normal. There were no obvious abnormalities on the whole-body CT scan; Gynecology Department Color ultrasound showed polycystic changes in both ovaries, and serum fasting insulin showed 6 times higher than the upper limit of normal!
Further examination of the OGTT (glucose tolerance test) showed high insulin secretion after taking sugar, consistent with hyperinsulinemia.
Wang Lin's preliminary examination results showed that: high insulin, high androgen, polycystic ovaries, and no metabolic abnormalities such as hyperlipidemia, high sugar, and high uric acid, which are different from the general metabolic syndrome.
The doctor further performed whole-exome sequencing on Wang Lin. The genetic test results showed that the insulin receptor (INSR) gene was mutated. Wang Lin was eventually diagnosed with a special type of insulin resistance syndrome - type A insulin resistance syndrome.
After a clear diagnosis, the doctor formulated a comprehensive treatment plan for Wang Lin. After several months of treatment, Wang Lin lost 3 kilograms in weight, his insulin resistance index dropped compared with before, and Wang Lin's life gradually got back on track.
It is understood that insulin resistance syndrome (IR) is a general term for a class of metabolic diseases. Classic IR mainly manifests as obesity, hypertension, hyperglycemia, hyperlipidemia and hyperuricemia. The above symptoms often exist at the same time, and women often have polycystic ovaries. syndrome.
Pang Shuguang, director of the Department of Endocrinology at Jinan Central Hospital, said that type A insulin resistance syndrome is a rare disease with an insidious onset. Early diagnosis, early intervention and regular follow-up are particularly important for patient prognosis.
First, patients are advised to engage in lifestyle intervention, that is, to adopt a healthy diet and moderate exercise to achieve weight control and improve insulin sensitivity.
Secondly, on the basis of lifestyle intervention, biguanide drugs and thiazolidinediones drugs that improve insulin sensitivity are appropriately added. At the same time, it is recommended that patients conduct regular testing of blood sugar and related indicators to evaluate the effect of treatment and adjust treatment plans in a timely manner.
Pang Shuguang reminds everyone that if there are changes in the body such as excessive weight gain, purple lines on the skin on the abdomen or thighs, rough skin on the back of the neck, armpits, etc., and dark wrinkles, you need to go to a regular hospital for treatment in time.
Qilu Evening News reporter Jiao Shouguang
Correspondent Zhao Mei