Guangzhou, April 4 (Reporter Cai Minjie) April 17 to 4 this year is the 15th National Cancer Prevention and Treatment Publicity Week. Wang Kun, vice president of the Cancer Hospital of Guangdong Provincial People's Hospital, said that there are many new advances in the treatment of each subtype of breast cancer, but the prevention and treatment of breast cancer still insists on early diagnosis and early treatment, and screening is required every year, "don't wait for any discomfort, or symptoms appear, before going to see a doctor."
Breast cancer is a relatively common malignant tumor and one of the leading causes of cancer-related death in women worldwide.
Wang Kun said that the incidence of breast cancer in China is about 40 per 10,70, but in first-tier cities such as Guangzhou, Shanghai and Beijing, the incidence of breast cancer is nearly 10 per <>,<>, "which may be related to changes in economic development level, lifestyle and diet." He added that increased stress and reduced fertility for women can increase the risk of breast cancer.
Breast cancer is not a single disease, but a combination of different types of diseases. Breast cancer can be used through gene sequencing and immunohistochemistry to determine the degree of amplification or expression of a certain driver gene in the tumor, and develop individualized treatment on this basis.
With the development of medical technology and the strengthening of tumor classification cognition, accurate diagnosis points out the direction for the treatment of different groups of breast cancer. Breast cancer treatment ushered in the era of classified treatment. According to Wang Kun, there are many new advances in the treatment of each subtype of breast cancer, such as chemotherapy plus immunotherapy for triple-negative breast cancer, and some new targeted therapies; There are many targeted therapeutic drugs for HER2-positive subtypes, such as novel ADC antibody conjugates, which play a very important role in HER2-positive subtype breast cancer.
In breast cancer, the positive subtype of HER2 (human epidermal growth factor receptor 2) accounts for about 20% to 25% of all breast cancers, which has the characteristics of high degree of tumor malignancy, rapid disease progression, easy metastasis, and high risk of death, which brings great threats to the life of patients. Among them, there is a group of people whose tumors are relatively inactive and cannot be targeted therapy, which is called HER2 low expression.
Wang Kun said that the new concept of 'HER-2 low expression' is mainly derived from the emergence of new ADC antibody conjugated drugs. In fact, HER-2 low expression is not completely without HER2, and there are also certain HER2 receptors on its surface, so innovative drugs such as ADC drugs can accurately combat HER-2 low-expression cancer cells and achieve the effect of killing tumors, bringing new hope to this part of patients.
"10 years ago, when I got breast cancer, most people probably thought it was to cut off the breast and then go on chemotherapy and radiation. However, after more than ten years of rapid development, more than half of breast cancer surgeries can achieve the effects of 'breast preservation' and 'breast reconstruction'. Wang Kun said that evidence-based medicine evidence shows that breast preservation can also be very effective, and in the long run, breast preservation may make women more confident and may benefit more.
But even so, early diagnosis and early treatment are still the focus of Wang Kun's emphasis. "Although the incidence of breast cancer in the United States is high, its mortality rate has been declining, and its success lies in early detection and early treatment." Wang Kun said that all women should be screened, generally speaking, women before the age of 40, go to color ultrasound every year, women after the age of 40 do color ultrasound and mammography every year, can screen out many early breast cancer patients.
Wang Kun said that in addition, it is necessary to develop good living and eating habits, and also learn to control emotions, because anxiety or mood swings can easily increase the risk of breast cancer. (End)