American actress Annie Wersching died on Sunday (local time) at the age of 45.
This was reported by the US broadcaster CNN, citing her husband Stephen Full and her publicist Craig Schneider.
"There is a huge hole in the soul of this family, but they left us the means to fill it," Fulls said in a brief statement.
The cause of death was given as cancer.
Wersching appeared in dozens of TV series in her career.
In addition to "Star Trek: Enterprise", later also "Star Trek Picard", she was also seen in "Bosch", "Vampire Diaries" and "General Hospital".
One of her most famous roles was that of FBI agent Renee Walker on the series "24".
Many colleagues expressed their sadness at the death of Annie Wersching on social media.
John Cassar, director and producer of 24, told US magazine Deadline: "My heart is broken into more pieces than I can count.
Annie came into my world with an open heart and an infectious smile.
She took my breath away with her great talent.
Annie became more than just a co-worker, she became a true friend to me, my family and all the actors and crew that worked with her.
Abigail Spencer, with whom Wersching played in the TV series Timeless, wrote on Instagram: "The best scene partner.
My nemesis in 'Timeless', with whom we could hardly remain serious.
This is a devastating loss to our community.
She's been the backbone of many of your favorite shows and ours.
If you needed someone to kick your ass or spice up a storyline or if you needed a lifeline, call Annie.
It's so hard... Steve... no words.
Wersching leaves behind her husband and three sons.
The youngest of them is four years old.