Changjiang Daily reporter Tian Qiaoping

　　In the past few days, reporters from Changjiang Daily have seen on social platforms and circles of friends that each bottle of human albumin and gamma balls, which originally cost more than 500 yuan, has been fired to 2,000 yuan, and each box of Paxlovid (Nimatevir tablets/Ritonavir tablets ) was fired to more than 5,000 yuan, and generally out of stock.

　　Since entering Wuhan Jinyintan Hospital in early January 2020 to set up a temporary ICU, Shang You, a professor of critical care medicine at Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, has been battling the new crown virus for 3 years.

On January 6, in an interview with reporters, Shangyou appealed not to stockpile drugs anxiously.

　　■ The therapeutic effect of gamma ball on new coronavirus infection is not clear

　　The full name of gamma globulin is human blood gamma immunoglobulin for injection.

The tenth edition of the World Health Organization's "Guidelines for Drug Treatment of COVID-19" and my country's "Diagnosis and Treatment Program for New Coronavirus Infection (Trial Version 10)" did not recommend gamma globulin as a treatment for new coronavirus infection.

In August 2022, the "Expert Consensus on the Diagnosis and Treatment of Severe and Critical New Coronary Pneumonia" formulated by the Chinese Medical Association's Critical Care Medicine Branch also did not include gamma ball as a drug for the treatment of new coronary pneumonia.

　　Shang You is the first author of the "Expert Consensus on the Diagnosis and Treatment of Severe and Critical New Coronary Pneumonia".

He said: "Gamma ball has a good therapeutic effect on the treatment of autoimmune diseases such as lupus erythematosus and Kawasaki disease in children, but the therapeutic effect on new coronavirus infection is not clear, and it is only used to treat related complications, such as children with multiple systemic diseases. Inflammatory syndrome, etc."

　　According to Shangyou, my country's "Diagnosis and Treatment Program for Novel Coronavirus Infection (Trial Version 10)" includes COVID-19 human immunoglobulin as an antiviral drug, but COVID-19 human immunoglobulin is not the same as the human immunoglobulin for injection that some people are hoarding now. Blood gamma immunoglobulin is completely different.

COVID-19 Human Immunoglobulin is purified from the plasma of patients who have recovered from COVID-19 to produce globulin containing antibodies from the recovered patients.

　　■ Human albumin cannot be used indiscriminately

　　Many people think that human serum albumin is a kind of nutritional medicine, which can provide nutritional support when seriously ill.

Shangyou said: "This cognition is wrong. Human albumin is a kind of medicine, and its use is also indicated, and it should not be used indiscriminately."

　　The "Expert Consensus on the Application of Human Serum Albumin in Critically Ill Patients" pointed out that the irrational use of human serum albumin is common, and 40% to 90% of the application of human serum albumin is not supported by clinical guidelines.

　　Shangyou told reporters that clinically, the albumin of some critically ill patients will decrease, which will indeed cause some problems and needs to be supplemented appropriately.

"Human serum albumin is not a cure-all drug. Patients with hypoalbuminemia can use human serum albumin. However, not all patients with hypoalbuminemia must use human serum albumin." Shang You said, if The patient is in the recovery period, eats well, the liver synthesis is normal, and the mental state is good, the albumin in his body will rise quickly.

For some critically ill patients, if the cause of low albumin cannot be found, the body produces insufficient albumin or loses too much albumin, albumin can be supplemented appropriately at this time.

"The use of human albumin is a means of symptomatic and supportive care."

　　Shangyou said that human albumin is not a nutritional medicine, nor is it used to improve immunity.

Nutritional medicine supplements the amino acids, fats, sugars, trace elements, vitamins, etc. needed by the human body.

　　■ Paxlovid is not a "magic drug"

　　On social media, Paxlovid (Nimatevir tablets/Ritonavir tablets) produced by Pfizer of the United States is regarded by some as a "miracle medicine" and ranks first in hoarding drugs.

"Paxlovid is not a specific drug, nor is it a 'miracle medicine'." Shang You said that Paxlovid was marketed in the United States with special approval and conditions, not unconditionally.

The first indication is to use it as soon as possible after infection (within 5 days), and the second is to use it for people with high-risk factors for severe disease (such as the elderly, people with basic medical conditions such as hypertension, diabetes, renal insufficiency, and tumors) disease) to prevent the development of severe or critically ill patients.

According to foreign clinical research, it is valuable in this respect.

　　Shangyou clearly opposes the blind hoarding of Paxlovid.

"First, compared with the original new crown strain and the delta variant, the virulence of the Omicron variant is further weakened, and most people will not be transformed into severe or critically ill patients after infection; second, Paxlovid is not only expensive, Moreover, it will interact with many drugs, resulting in decreased efficacy or aggravated side effects."

　　In a form sent by Shangyou that Paxlovid interacts with other drugs and is listed as "prohibited in combination", the reporter found that there are 18 kinds of drugs that patients with chronic diseases often take, including lipid-lowering drugs, anticoagulants, hypnotic and sedative drugs Drugs, bronchodilators, gastrointestinal drugs, anti-infective drugs, anti-tumor drugs, immunosuppressants, etc.

Shang You said: "Blindly hoarding medicines and taking them blindly will not only cause economic losses, but also pose a huge hidden danger to drug safety."

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