The theory of collaterals is a clinical application theory to study the occurrence and development of collateral diseases, basic pathological changes, characteristics of clinical syndromes, and medicines based on syndrome differentiation.
The choroid is the network structure that runs the blood in the meridian system, which permeates and nourishes the organs and tissues of the whole body. The disease of the choroid is the basis for the pathogenesis of various clinical diseases. In-depth study of the occurrence and development of the choroid and the law of syndrome differentiation and treatment can guide the prevention and treatment of various refractory diseases in clinic. have important value.
Inheriting and developing the bloodline theory, constructing the context theory
Context theory and meridian theory together constitute a complete meridian theory, forming a TCM academic system with visceral symptoms as the core, meridians as the hub, and Qi and blood as the basis.
However, due to the confusion between the concept of meridians and meridians, the history of the theory of collaterals has been absent.
"Bloodline" as a medical concept has undergone a long historical evolution process. Ancient Chinese ancestors had an intuitive understanding of the bloodline in the life practice of drinking blood, and expressed it with the hieroglyph "" or "" with the meaning of water flow.
The functions and distribution of human meridians, as well as the diagnosis and treatment of diseased meridians, are discussed in ancient books such as "Eleven Moxibustion Meridians of the Foot and Arms", "Eleven Yin and Yang Moxibustion Meridians", "Maid of Pulses", and "The Death of Yin and Yang Meridians" unearthed from the tombs of the Western Han Dynasty.
The "Huangdi Neijing" in the Spring and Autumn Period clearly put forward the concept of "blood veins", pointing out that the veins are the physical organs that contain blood, and are also the channels for blood to run.
Moreover, medical books such as "The Yellow Emperor's Classic of Internal Medicine" and "Treatise on Febrile Diseases and Miscellaneous Diseases" have always paid equal attention to qi and blood, and meridians and collaterals to study the law of disease. Clinical application value.
Therefore, the establishment of the meridian theory not only adapts to the social needs of the prevention and treatment of major diseases such as cardiovascular and cerebrovascular diseases that seriously endanger human life and health, but also restores the historical original appearance of the meridian theory.
Academician Wu Yiling's team traced the source and explored the current, and systematically constructed the theory of choroids, pointing out that the choroids branch out from the blood vessels, run the blood, and permeate the network system that nourishes the whole body, including small blood vessels, microvessels, and microcirculation.
And put forward the core content of the context theory - the theory of battalion and defense: camps are in the veins, and the guards are outside the veins, the camp and the guards are blocked, the blood coagulation does not flow, the blood vessels are passed down, the blockage is blocked, and those who damage their hearts, adjust their camp and guards, revealing Occurrence, development and treatment principles of choroid lesions.
Using Yingwei theory to analyze 2487 first prescriptions for the treatment of vascular diseases over the past 2000 years, the prescriptions are completely in line with the medication rules of regulating Yingwei qi and blood. Qiangxin Capsule Recipe.
At the same time, according to the identity of the structure and function of the collaterals and blood vessels, it is proposed that "Sun collaterals - microvessels" is the theoretical combination point and therapeutic breakthrough of Chinese and Western medicine research on microvascular disease, and microvascular disease is precisely the key to improving the clinical efficacy of cardiovascular and cerebrovascular diseases. It is also an international problem that is difficult to break through.
The acceptance evaluation opinion of the 973 project expert group believes that: "The Context Theory, Yingwei Theory has formed a new theory to guide the prevention and treatment of major diseases of microvascular disease, and it belongs to the original achievement of academic research on traditional Chinese medicine."
Context Theory to Solve the Problem of Coronary Heart Disease
Coronary heart disease is the full name of coronary atherosclerotic heart disease, which refers to the heart disease caused by atherosclerosis of the coronary arteries, which causes the stenosis or occlusion of the official cavity, resulting in myocardial ischemia, hypoxia and even necrosis. The coronary arteries are the blood vessels that supply the heart. Therefore, the stenosis or complete blockage of the coronary arteries can affect the blood supply of the heart. The consequence is that the systolic, diastolic, and pumping functions of the heart are abnormal. Breathing difficulties, arrhythmias, heart failure, shock, and even death.
Studies have shown that in patients with coronary heart disease, the incidence of acute myocardial infarction without reflow is as high as 37%, and the incidence of acute myocardial infarction with arrhythmia is as high as 75% to 95%.
"Microcirculation" pointed out that the essence of cardiovascular disease is microcirculation disorder, which is the core mechanism of the occurrence and aggravation of cardiovascular disease.
Aiming at the core mechanism of microvascular disease, Academician Wu Yiling led a team to carry out a series of basic and clinical research, and developed Tongxinluo Capsule for ischemic heart disease, Shensong Yangxin Capsule for arrhythmia and Qi for heart failure Liqiangxin Capsules.
Studies on myocardial infarction have confirmed that Tongxinluo capsules developed under the guidance of the choroid theory can significantly improve the curative effect of acute myocardial infarction by 20%, significantly reduce the size of myocardial infarction, and improve cardiac function. The key mechanism for exerting the above curative effect is to protect myocardial infarction Blood microvessels, improve microvascular blood flow in ischemic areas.
Therefore, the "Expert Consensus of Integrated Traditional Chinese and Western Medicine Diagnosis and Treatment of Acute Myocardial Infarction" issued by the Chinese Association of Integrative Medicine.
In addition, it was also included in the "Chinese Expert Consensus on Diagnosis and Treatment of Coronary Microvascular Diseases", "Chinese Expert Consensus on Diagnosis and Treatment of Coronary Artery Spasm Syndrome" issued by the Chinese Medical Association and "Percutaneous Coronary Intervention" issued by the Chinese Association of Traditional Chinese Medicine. Expert consensus on TCM diagnosis and treatment for perioperative myocardial injury.
Research on arrhythmia has confirmed that Shensong Yangxin Capsule developed under the guidance of the choroid theory has the functions of treating both speed and slowness and integrating rhythm regulation. It can reduce premature ventricular contractions while improving cardiac function, and can also treat sinus bradycardia with ventricular Premature beats, which increase ventricular rate while reducing ventricular premature beats.
The total effective rate of Shensong Yangxin Capsule in the treatment of ventricular premature beats is better than that of mexiletine, the curative effect of treatment of paroxysmal atrial fibrillation is comparable to that of propafenone, and it also has significant curative effect on bradyarrhythmia.
Its mechanism is also related to the protection of cardiac microvessels.
Therefore, Shensong Yangxin Capsule is listed in the "Chinese Expert Consensus on Ventricular Arrhythmia", "Atrial Fibrillation: Current Understanding and Treatment Recommendations", "Guidelines for Rational Drug Use for Arrhythmia" and "Thirteen Five" planning textbook "Internal Science".
Studies on heart failure have confirmed that Qili Qiangxin Capsule, developed under the guidance of the choroid theory, can reduce the level of NT-proBNP in patients with chronic heart failure, improve cardiac function, increase left ventricular ejection fraction, increase the 6-min walking distance in patients with heart failure, and reduce compound The incidence of end-point events was significantly improved by 16% on the basis of international standard treatment of western medicine, and its mechanism was also to protect the cardiac microvessels.
"People's Daily" quoted the "American Journal of Cardiology" comment: "Chinese herbal medicine brings new hope for the treatment of heart failure."
Qili Qiangxin Capsule is listed in the Chinese Medical Association's "Guidelines for Diagnosis and Treatment of Heart Failure in China" and "Guidelines for Diagnosis and Treatment of Dilated Cardiomyopathy in China".
Context Theory to Solve the Problem of Ischemic Cerebral Infarction
In my country, at least 1 in every 5 deaths died of cerebrovascular disease. Microvascular injury is an important factor leading to the destruction of the blood-brain barrier and the expansion of cerebral infarction in patients with acute cerebral infarction.
Therefore, under the guidance of the choroid theory, the treatment strategy for cerebral infarction is to protect the microvessels in the ischemic area.
Studies on ischemic cerebral infarction have confirmed that Tongxinluo capsule developed under the guidance of the choroid theory can protect the blood-brain barrier, reduce the volume of cerebral infarction, and improve neurological function, and its mechanism is also related to the protection of microvessels in the ischemic area.
The drug is listed in the "Expert Consensus on the Diagnosis and Treatment of Chronic Cerebral Ischemia with Integrated Traditional Chinese and Western Medicine" issued by the Beijing Association of Integrative Medicine.
Context theory solves the problem of diabetic nephropathy
According to statistics, there are 129.8 million diabetic patients in my country, and the prevalence of diabetic nephropathy is 30% to 50%.
Studies have shown that microvascular damage is also the core pathogenesis of diabetic nephropathy, so protecting the microvessels of diabetic patients is also a key measure to prevent and treat diabetic nephropathy.
Studies on diabetic nephropathy have confirmed that Tongxinluo Capsules developed under the guidance of the choroid theory can protect microvessels and nephrons, inhibit renal fibrosis and improve renal function.
The construction of the context theory and its guidance on the prevention and treatment of microvascular lesions have set a model for the inheritance and development of traditional Chinese medicine
The construction of the context theory and its application research inherit the discussion of the theory of blood vessels in traditional Chinese medicine, combine it with modern science and technology, adhere to the research principle of multi-disciplinary cross-integration with traditional Chinese medicine as the main body, systematically sort out the relevant discourses on the blood vessels and the theories of the blood vessels in the past dynasties, and clarify the concepts. Connotation and extension, combined with clinical practice and modern multi-scientific knowledge to interpret its scientific connotation, put forward new theoretical hypotheses, with "originating from clinical, basic research, guiding clinical" and "overall design, branch verification, system integration, outstanding "Innovation" as the guiding ideology, exerting the theoretical characteristics of the qi and blood-related context theory, focusing on the common pathological links of vascular lesions and the common pathogenesis of microvascular damage, clarified the pathological evolution of vascular lesions and the effect of collateral-draining drug intervention. The analysis turned the hypothesis into a theory, established the context theory with general guiding significance for vascular disease, and improved the treatment level of vascular disease, especially microvascular disease.
Evaluation of the National 973 Program Project Acceptance Expert Group: This study "created a new model of TCM academic innovation and transformation that integrates 'theory + clinical + new drugs + experiment + evidence-based'. The combination of traditional TCM theoretical innovation and modern science and technology has produced significant The original achievements have made a demonstration for the inheritance and innovative development of traditional Chinese medicine.”
(Yang Yi)