China News Service, Shanghai, May 19 (Chen Jing, Zhu Hong, Ding Guolian) The reporter was informed on the 19th that the latest research explanation by Chinese scholars has confirmed the oocyte origin of diabetes, and revealed the intergenerational genetic mechanism of diabetes, which is helpful for human understanding and prevention. The control of chronic diseases in adults such as diabetes provides a new scientific perspective.

　　The results of this collaborative research by the Chinese Ministry of Education's Key Laboratory of Reproductive Genetics/Fudan University Huang Hefeng and the Chinese Academy of Sciences/Fudan University Xu Guoliang's team were published online in the latest issue of the internationally renowned journal Nature.

It is understood that the researchers looked directly at the role of eggs as a carrier of intergenerational inheritance, outlined the key to decryption Tet3 from a molecular perspective, opened a unique paternal genetic route, and achieved a major breakthrough in the study of developmental adult diseases.

It is reported that Tet3 is a DNA demethylase and a maternal effector.

　　In the 20th century, British scholar Barker proposed that exposure to adverse environmental conditions during the intrauterine period (fetal period) would lead to an increase in the incidence of chronic diseases such as diabetes and hypertension in adulthood, providing a new idea for the pathogenesis of chronic diseases in adults.

At present, this type of chronic diseases such as metabolic and cardiovascular diseases originating in early life are generally referred to as developmental diseases in clinical practice. burden, seriously affecting the health of the Chinese population.

　　Academician Huang Hefeng said: "The health management and treatment of patients with chronic diseases such as diabetes takes up a lot of public health resources, and the society has to deal with the heavy burden brought by such high-incidence diseases. The current effect of chronic disease prevention in adults is not satisfactory, forcing us not to open We must seek breakthroughs from new angles.”

　　The team of Huang Hefeng, an academician of the Chinese Academy of Sciences, has long been committed to the research on the pathogenesis of adult diseases caused by maternal exposure to environmental factors during pregnancy.

They found that exposure to factors such as high sugar in the uterus during pregnancy can form intergenerational inheritance, and found that the origin of the disease can be moved forward to the pre-pregnancy (gamete development period), and took the lead in proposing the theory of "gametogenic adult disease".

Compared with the direct exposure of the fetus during pregnancy, how gametes or germ cells transmit adverse environmental factors to offspring, the relevant mechanism of action has always been a topic explored by Huang Hefeng's team.

　　The research group of Academician Huang Hefeng and the research group of Xu Guoliang, academician of the Chinese Academy of Sciences, cooperated with the research group of Xu Guoliang, an academician of the Chinese Academy of Sciences. They took pre-pregnancy diabetes as an entry point, and finally found that female eggs can mediate the passage effect of diabetes, and found the key to open the egg-derived intergenerational inheritance model Tet3, And explained the regulatory pathways and specific ways of intergenerational inheritance.

　　Diabetes is one of the most important chronic diseases affecting human health, with a high incidence and hidden incidence. There are many diabetic women in reproductive age worldwide.

Taking pre-gestational diabetes as an example, the research team established a diabetic mouse model, obtained oocytes from diabetic mice and sperm of normal male mice for in vitro fertilization, and implanted the early embryos formed in vitro into the uterus of normal surrogate mother mice for continued development.

The offspring mice have impaired glucose tolerance, mainly manifested as insufficient insulin secretion.

　　The researchers found that Tet3 was significantly reduced in the egg cells of diabetic mice.

The research group of Academician Xu Guoliang from the collaborative team revealed the role of Tet3 in egg cell reprogramming.

Interestingly, even though the eggs were exposed to high glucose, the target genes of Tet3 affecting offspring onset were not the maternal genes, but the paternal genes.

　　The research team also obtained relevant samples from clinical diabetes patients in the reproductive centers of several hospitals in Shanghai and Zhejiang, indicating that the previous findings of the research team in the mouse model have clinical significance.

Academician Huang Hefeng said: "The research results of a series of developmental diseases, including this study, have brought us inspiration. We should fully understand the possibility and importance of intervention in early life, and change the thinking of disease prevention and control."

　　The expert said: "This research provides a key theoretical basis for the concept of early life intervention, and is an important prerequisite for our subsequent clinical research and practice." It provides a new perspective and strategy to improve the health of China's population.

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