Large-scale analysis conducted by RIKEN and others has shown that mutations in genes known to increase the risk of developing breast cancer also increase the risk of gastric cancer, and early diagnosis and new treatments will be made in the future. It is expected to lead to the development of the law.
Some cancers are vulnerable to mutations in the gene, and if there is a specific mutation in a gene called "BRCA", breast cancer is more than 10 times more likely to develop, including ovarian cancer and prostate cancer. It is also known to increase the risk of pancreatic cancer.
A group of team leaders, Yukihide Momozawa of RIKEN, analyzed the genetic information of more than 100,000 people stored in a domestic "biobank" and investigated the relationship between mutations and cancer risk.
As a result, among the "BRCA" genes, those with a mutation in "BRCA1" were 5.2 times more likely to develop gastric cancer, 17.4 times more likely to have biliary tract cancer, and "BRCA2" than those without the mutation. People with mutations were found to be 5.6 times more likely to develop esophageal cancer and 4.7 times more likely to have biliary tract cancer.
There are many patients with these cancers in East Asia such as Japan, and it is expected that it will lead to early diagnosis and development of treatment methods because it was found for the first time that mutations in the "BRCA" gene are involved. ..
Team leader Momozawa said, "There are already therapeutic drugs that have been shown to be effective when there is a mutation in this gene, and if the effects are confirmed in clinical trials, we can expect the drug to be used."