The key to the relationship between blood group and the severity of Covid-19 lies in proteins

The analysis of more than

whose objective is to determine their relationship with

2 and, consequently, identify which subgroups may be linked to the

, has once again suggested the role of the different blood groups in the origin of the most serious forms of the disease, as revealed by some studies focused on this aspect at the beginning of the pandemic.

This is the first study to evaluate

of proteins and whose data, published by PLOS Genetics, open up new perspectives in the

of severe covid-19.

According to

, Professor of Genetics at the Institute of Psychiatry, Psychology and Neuroscience (IoPPN) at King's College London, and a co-author of the article, "out of thousands of blood proteins, we have

that have some kind of relationship causal with the

of the disease. In addition to being a way to continue investigating and understanding the mechanisms of covid-19, the

is to develop

, as well as

".

Higher and lower risk

The study, funded in part by the Maudsley Biomedical Research Center of the National Institute for Health Research (NIHR), in the United Kingdom, has used a

.

Of the total, 6 have been identified

of severe covid-19 and

.

The protein

, for which a causal connection has been observed

, determines blood groups in humans, which "suggests that

play a decisive role in people developing

", indicates

, of the IoPPN.

"Focusing on this group of proteins is a critical first step in

for developing new treatments."

Study co-author Vincent Millischer

, a professor at the Medical University of Vienna in Austria, explains that in the study, the groups were defined by their

for different blood protein levels, which "allows us to assess the causal direction between

and the

of covid-19, while avoiding the influence of environmental effects."

Severity due to covid-19 in this study was defined by

, on the one hand, and

.

The

was causally associated with both a

and the

, a fact that supports previous studies on blood group and a

from this viral disease.

For example, among the different works published in this regard, a

investigation in Blood Advances, endorsed by the American Society of Hematology, concluded that people with

were

when infect.

He also observed a lower prevalence of

and

in relation to those infected with group A, B or AB6.

Following the line of this previous research, scientists have observed that the

is higher in individuals positive for covid-19.

Group A, candidate for follow-up

"Precise blood type is not associated with risk of severe COVID-19, but since

have found that the proportion of type

is higher in COVID-19 positive individuals, we think blood type A is the most likely candidate for

" says

of IoPPN.

In his opinion, the enzyme

of an individual.

"The data links it to both the risk of hospitalization and the need for respiratory support or death."

Research has also identified

, associated with a

and

.

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