- Russia and Ukraine have always been fraternal countries.
I am against this fratricidal war and believe that they should lay down their arms and negotiate, he tells AFP.
The statement comes somewhat unexpectedly as Depardieu is friends with Russia's president and has long said he admires Vladimir Putin.
Just last month, he posted a picture on Instagram where he embraces Putin, and on French television he said that one should "leave Vladimir alone".
Gérard Depardieu caused some uproar when he left France in 2013 and moved to Russia in protest of a bill on higher taxes for the rich.
He received a Russian passport from Putin the same year.
In 2015, he was blacklisted by Ukrainian authorities who banned him from visiting Ukraine for a five-year period after he refused to recognize the independence of the former Soviet state.
Depardieu broke through outside France in 1990 in the comedy "Married on pretend" and has since appeared in a long line of Hollywood productions.