On New Year's Eve, the window of the Cologne constituency office was thrown in by Federal Health Minister Karl Lauterbach (SPD).
The state security has started the investigation, said a spokesman for the police.
The Cologne “Express” had previously reported on the attack.
Lauterbach told the German Press Agency on New Year's Day that due to previous damage to property with slogans and corresponding threatening emails, he assumed that the renewed attack on his office was carried out from among the ranks of radicalized vaccination opponents and corona deniers.
"These people do not represent society, where the overwhelming part is really sticking together and trying to do everything against the pandemic," said the minister.
“You represent a very small splinter group that self-righteously believes that they have to take a different path here and that got lost in the process.
That's just sad. "
On December 10, the office was smeared with slogans such as “Minister of Disease”, “Murderer” and “Psycho Lauterbach”.
When exactly at the turn of the year the more than fist-sized hole was punched in the window of the shop is unclear, it said from the local SPD club.