It is said that cells that have aged and do not work normally are accumulated in the human body such as lifestyle-related diseases, which are more likely to occur with age.
Groups such as Juntendo University have announced that they were able to remove "aging cells" by administering immune-stimulating substances such as vaccines in mouse experiments, which may lead to treatment of aging-related diseases in the future. There is.
In lifestyle-related diseases such as diabetes and arteriosclerosis, and Alzheimer's disease, it is thought that chronic inflammation occurs due to the accumulation of cells that have aged and stopped dividing.
Research groups such as Juntendo University have noticed that a large amount of protein called "GPNMB" appears on the surface of "aging cells", and it may be possible to remove "aging cells" by targeting and attacking this protein by the action of immunity. I wondered if there was one.
Then, when an experiment using mice was conducted and the substance of the artificially made "GPNMB" fragment was administered like a vaccine, immune cells were stimulated to produce antibodies, and "senescent cells" were actually removed. It means that I was able to do it.
In addition, the symptoms improved in diabetic and arteriosclerotic mice, and the decline in physical function was suppressed in aged mice.
Professor Toru Minamino of Juntendo University says, "In the future, it may lead to the treatment of diseases that increase with age, such as Alzheimer's disease, so I would like to proceed with research."