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Pfizer reported Monday that it had begun the first human trials of a flu vaccine with messenger RNA technology, already used in its Covid-19 vaccine.
American biotech company
Moderna had also said it had launched trials
of such a product in early July.
The Pfizer clinical trial is taking place in the United States and will evaluate the safety of a dose of the new vaccine, as well as its immunogenicity (ability to induce an immune response), in healthy people between 65 and 85 years of age.
It will include a few hundred participants, according to clinical trial details published on a US government website.
Current flu vaccines use inactivated viruses, a time-consuming process.
The constantly changing target strains of the virus should be chosen for vaccine development about six months before the start of the seasonal epidemic.
The
efficacy of
currently used
vaccines
is typically
between 40% and 60%
.
"The flexibility of messenger RNA technology and its rapid production could allow a better association with the strain (of circulating virus), greater reliability in delivery and
the opportunity to improve the efficacy of current influenza vaccines
," he noted. Pfizer in its statement.
The World Health Organization estimates that the flu causes between
three and five million cases of serious illness
and between 290,000 and 650,000 deaths each year.
In addition to the flu, Pfizer said it plans to study the use of messenger RNA technology against other respiratory viruses, as well as against genetic diseases or cancers.
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