New nanomaterials can enhance the anti-coronavirus effect of dendritic cell vaccines
Science and Technology Daily, Beijing, September 2 (Yu Qunfang, Guan Tong, reporter Zhang Qiang) The reporter learned from the Academy of Military Medicine on the 2nd that the research team led by researcher Zhan Linsheng of the Academy found that new nanomaterials can enhance the anti-coronavirus effect of dendritic vaccines .
Relevant research results were published in the authoritative journal "Advanced Materials" in the field of international materials.
If T cells are the heroic fighters against disease, infection and tumor cells in the body, dendritic cells are "scouts" and "correspondents" that help T cells find viruses, bacteria, tumor cells and other "bad molecules".
In view of the important role of dendritic cells in initiating the immune response, people have successfully established an in vitro induction culture platform for dendritic cells to carry out more efficient in vitro antigen loading and activation of dendritic cells, and obtain fully functional dendrites. The shape cells are fed back into the recipient's body to initiate a specific immune response.
It is understood that the research team led by researcher Zhan Linsheng is committed to the application of nanotechnology in the treatment of blood transfusion.
In this research, the team innovatively used large-scale (sheet diameter greater than 1 micron) graphene oxide nanosheet materials to engineer dendritic cell vaccines, thereby promoting the "immunity between dendritic cells and T cells" The formation of "synapses" and the aggregation of cell clusters reveal for the first time that two-dimensional nanosheet materials have potential applications as adjuvants for broad-spectrum dendritic cell vaccines.
The study shows that graphene oxide, a two-dimensional nanosheet material, can greatly enhance the anti-coronavirus effect of dendritic cell vaccines by regulating the formation of "immune synapses" between dendritic cells and T cells.