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An experimental monoclonal antibody treatment against Covid-19 being developed by Eli Lilly and AbCellera Biologics can "potently" neutralize numerous variants of the
coronavirus
, including those first identified in the United Kingdom, Brazil, South Africa, California and New York, according to scientists have discovered in experiments with test tubes.
The antibody - known as LY-CoV1404 or LY3853113 - works by attaching itself to a site in the virus that has shown few signs of mutation, meaning
the drug
is
likely to remain effective over time
, researchers say in a report. posted Friday in
bioRxiv
ahead of peer review.
"New variant-resistant treatments, such as LY-CoV1404, are desperately needed, as some of the existing therapeutic antibodies are less effective or ineffective against certain variants and
the impact of variants
on the efficacy of the
drug is still
not well understood.
vaccine, "wrote the research team.
A spokesman for AbCellera said the company plans to release information on human trials of the drug on Tuesday.
(https://bit.ly/3gYQnAU)
These are the preliminary conclusions of one of the latest scientific studies on the new
coronavirus
and efforts to find treatments and vaccines for Covid-19, the disease caused by the virus.
Antibodies, detectable at 12 months
Some Covid-19 survivors infected early in the
coronavirus
pandemic
still have
detectable antibodies to the virus a year later
, according to another new study on the disease that has caused a pandemic.
American doctors collected blood samples from 250 patients, including 58 who had been hospitalized for Covid-19 and 192 who had not required hospitalization.
Six to 10 months after diagnosis, all former inpatients and 95% of outpatients continued to have
neutralizing antibodies
, according to a report published Sunday in
medRxiv
prior to peer review.
In the small subgroup of those who were followed for a full year, 8 of 8 people who had been hospitalized continued to have antibodies, as did 9 of 11 former outpatients.
Antibody levels at the time of follow-up
were correlated with age and severity
of Covid-19 disease.
The researchers reported that older age was associated with higher levels of neutralizing antibodies, while the levels were "lower and more variable" in participants younger than 65 who experienced less severe Covid-19 and did not require hospitalization.
They said vaccinating Covid-19 survivors "would be prudent" because vaccine-induced protection against the virus will likely be more durable than antibodies induced by mild COVID-19.
According to the criteria of The Trust Project
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