Coronavirus Last minute
It is one of the great mysteries of the coronavirus, knowing why there are people with Covid-19 who do not develop any symptoms.
at Aarhus University and Aarhus University Hospital
in Denmark have discovered that the answer to this mystery is that the SARS-CoV-2 virus can hide its genome from being recognized.
The key is in the so-called alveolar macrophages, which determine how quickly an immune response to a coronavirus infection can occur.
These alveolar macrophages may be the first to encounter the coronavirus during an infection, and their reaction to the virus has a profound impact on the outcome of the infection.
published in the journal EMBO Reports
, has shown that the SARS-CoV-2 virus is capable of inhibiting the production of interferon in infected epithelial cells.
The results suggest that the coronavirus can hide its genomic material so that it is not recognized in alveolar macrophages, without inducing the production of interferons.
Recovered patients may be carriers of the virus
The detection of asymptomatic is a key factor to stop the spread of the coronavirus but it also requires importance to control the transmission of those patients who have overcome the disease but are still carriers of the virus.
A study conducted by the Polliclinico Universitario Fondazione Agostino Gemelli in Rome, Italy, has reported that about 17% of patients who were considered fully recovered from COVID-19 tested positive for the virus in follow-up tests.
In the work, published in the American Journal of Preventive Medicine, patients who continued to have respiratory symptoms,
especially sore throat and rhinitis
, were more likely to have a new positive test result.
This suggests that the persistence of these two symptoms should not be underestimated and that they should be adequately evaluated in all patients considered recovered from COVID-19.
The study included 131 patients who met the World Health Organization (WHO) criteria for
suspension of quarantine at least two weeks before the follow-up visit
WHO criteria specify that the patient must be fever-free without fever-reducing medications for three days, show improvement in any COVID-19-related symptoms, be more than seven days late in the onset of symptoms, and give two times negative results for the SARS-CoV-2 virus, with a minimum interval of 24 hours, with PCR tests.
Up to 22 (16.7%) of the patients tested positive again.
There were no significant differences between patients with positive and negative results in terms of age or gender.
None of the patients had a fever and all reported an improvement in their general clinical condition.
The time elapsed since the onset of the disease, the number of days of hospitalization and the treatments received during the hospitalization were not significant.
"Our findings indicate that a remarkable rate of recovered patients with COVID-19
could continue to be asymptomatic carriers of the virus
. The main question for containment of the SARS-CoV-2 pandemic infection that still needs to be answered is whether the persistent presence of Virus fragments means that patients are still contagious. The PCR test looks for small fragments of viral RNA. A positive swab test can reveal whether patients are still shedding viral fragments, but is not able to discern whether or not they are infectious, "he explains. the study leader, Francesco Landi.
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