For the first time, the Realysa study, which aims to accelerate research on the symphoma, will be conducted in real life with patients.

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ergei Karpukhin / SIPA

  • A national study called Realysa is currently being carried out across France.

  • It aims to accelerate research on lymphoma and the care of patients.

  • For the first time, this study will be conducted "in real life" with 6,000 patients.

Speed ​​up research on lymphoma and patient care.

This is the goal of a national study called Realysa conducted by Lysa (a cooperative group in hematology specializing in lymphoma), in collaboration with the network of cancer registries Francim and the HCL, civil hospices of Lyon.

An "ambitious" study that will follow for nine years 6,000 new patients with lymphomas distributed throughout the territory.

“The objective is to be able to improve our knowledge of these complex diseases and to better understand the patient care pathway as well as the effectiveness of the treatments”, explains Fanny Cherblanc, head of clinical projects stationed at Lysarc, operational structure in charge of setting up the study.

“The particularity of this study is to be in real life.

We collect data every day on patients of all ages who are not included in clinical trials, which are generally very selective, adds Fanny Cherblanc.

The only data we have today are those from these trials in which only 10 to 15% of patients participate ”.

Very few of them elderly or suffering from heart problems, hence a significant loss of information concerning the vast majority of patients.

18,000 new cases each year in France

The researchers thus aim to better understand the environmental, medical or personal factors that may explain the appearance of the disease and its course.

But also to decipher the reasons why some patients respond well to treatments and others relapse despite an improvement, since the early 2000s, in the management of lymphoma, considered the "sixth cancer" in France with 18,000 new cases every year.

"It will also be a question of measuring the repercussions of lymphoma and the treatments on the quality of life of patients, whether at home, at work, in family", continues the head of clinical projects.

Complete clinical trials

"Many hematology departments are mobilizing across France to recruit patients", adds Pr Hervé Ghesquières, hematologist at Lyon-Sud Hospital and coordinating investigator of the study, specifying that 1,000 people have integrated it. since its launch in November 2018.

However, there is no question of opposing this project to ongoing clinical trials.

“Our study complements them,” specifies Fanny Cherblanc.

For example, we will seek to know whether a particular treatment is as effective in real life as in clinical trials.

This can help to consolidate reimbursements for existing drugs, ”she concludes.

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