• Cleveland, U.S. Surgeons Successfully Perform World's Largest Face Transplant

Connie Culp, the first recipient of a partial facial transplant in the United States, died at 57, the Cleveland Clinic of the state of Ohio confirmed on Saturday , where she underwent the delicate operation almost 12 years ago.

The health center did not mention any cause of death on Friday night in a message from her Twitter account, citing one of her doctors, Frank Papay, who mentioned her as a "great pioneer."

"Their decision to undergo a sometimes daunting procedure is an enduring gift for all of humanity," added Papay, director of the clinic's Institute of Dermatology and Plastic Surgery .

Culp was seriously injured in 2004 when her husband shot her and then shot himself.

The bullet impact destroyed his nose, cheeks, palate, and right eye. His partner's injuries were much less, and he ended up being jailed for seven years for the attack. Culp had 30 surgeries before undergoing transplant surgery in 2008 at the Cleveland Clinic, an intensely complex procedure that took 22 hours over two days.

But the operation, performed around the world just a few dozen times, can mean a lifelong struggle to prevent the body from rejecting implanted tissue. And medications designed to prevent such rejection can lead to a number of infections and even cancer.

This woman, a mother of two, dedicated herself after the operation to giving talks about domestic violence and encouraging other people who had face transplants, including Charla Nash, a Connecticut citizen who was mutilated by a pet chimpanzee.

According to the criteria of The Trust Project

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