Elucidation of the mechanism of change to "oocytes" "In the future in fertility treatment" February 14 5:07
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A group at Kyoto University announced that it has clarified the mechanism by which mouse germ cells are transformed into "oocytes" that are the basis of eggs. In the future, the results will lead to treatment of infertility.
A group of Professor Toshinori Saito of the Kyoto University Institute of Advanced Studies has created germ cells from ES cells that can be transformed into various cells through research using mice, and turned them into "oocytes" that are the basis of eggs. We have succeeded in differentiating, but we did not know the specific mechanism why it differentiated.
This time, the group investigated in detail which genes are involved in the differentiation of oocytes artificially produced from ES cells and mouse fetal oocytes.
As a result, they found that the gene "Zglp1" plays an important role in differentiating into oocytes, and found that mice that did not work with this gene could not produce eggs, resulting in infertility. is.
Professor Saito says, "I would like to clarify the process of becoming an egg in more detail in the future to help establish a method of treating infertility."
The results of this research will be published on the 14th in an electronic version of the American science journal Science.