Analgesics and kidneys .. How do you plant poison in your body?

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The yellow disk, or as some patients call it "quick", is the story of a drug turned into candy, without a home, and not absent from a single pharmacy; it is cut and sold alone by a single pill, which is easier to obtain, In his body, or strained by a headache in his head! And how not? And the ways are all open, the drug is sold over-the-counter (OTC) taken by the young, before the big, in all forms and situations, and no one asks anyone, why take it? Did you know the best way to use it? Not to mention his dose, contraindications, and the dangers of continuing him for a long time, without reference to a doctor or pharmacist, a medical disaster began to spread in various countries, especially Egypt, which pays the highest tax of misuse, what is the story of painkillers - non-steroidal anti-inflammatory drugs? How do we use them correctly? What are their damages? How does it work?

What are nonsteroidal anti-inflammatory drugs?

Non-steroidal anti-inflammatory drugs (NSAIDs) are a very common type of medication - many of which are available without a prescription - that can reduce pain and inflammation and reduce body temperature during fever, and also have some undesirable side effects such as reducing the production of substances that protect the stomach, Platelets - the vital cells in the formation of clots to stop bleeding - stopped working effectively, reducing the amount of blood - significantly - that flows into the kidneys.

How do NSAIDs work?

Non-steroidal anti-inflammatory drugs work by inhibiting an enzyme - a chemical that causes other chemical reactions - called cyclooxygenase enzymes sometimes referred to as COX - and is a crucial step to producing chemicals called prostaglandins, which have different roles, The feeling of pain and therefore by stopping the enzyme, are produced at a lower rate, which reduces inflammation and the absence of pain, and this is the main idea on which the painkillers.

What types of analgesics?

The non-steroidal anti-inflammatory drugs are "non-selective" and "selective" but understanding their differences requires further explanation as to how they work; the cyclooxygenase is already present in two different forms, COX-1 and COX-2, each with a similar but differentiated function COX-2 is the enzyme responsible for inflammation and fever, while COX-1 already performs other functions such as protecting the mucous membrane in the stomach - stomach lining - of the acid produced by the stomach naturally. COX-1 also plays a role in the formation of platelets together to form Clots.

1. Non-selective anti-inflammatory drugs
Non-steroidal non-steroidal anti-inflammatory drugs are drugs that inhibit both types of COX and are therefore associated with an increased risk of gastric ulcer. Examples of non-steroidal non-steroidal anti-inflammatory drugs include aspirin, diclofenac, ibuprofen, naproxen, indomethacin, ketoprofen and pyroxicam.

2. Anti-inflammatory drugs
The selective non-steroidal anti-inflammatory drugs only inhibit the COX-2 enzyme, allowing Prostaglandins to protect the stomach, while in turn relieving fever, pain and inflammation. Optional non-selective anti-inflammatory drugs are silicoxib and meloxicam.

What is used?

Non-steroidal anti-inflammatory drugs can play a role in treating many different conditions caused by inflammation, pain or both. Non-steroidal anti-inflammatory drugs can also be used in the treatment of: rheumatoid arthritis, acute gout, menstrual pain, bone pain, headache and migraines Postoperative, mild to moderate pain due to inflammation and injury of the tissues, renal colic, reduction of pain and symptoms associated with cold and influenza, and non-steroidal anti-inflammatory properties of the heart - Aspirin more common - by stopping the formation of clots.

Effect on the body

The most common effects:
Nausea.
Indigestion.
Ulcers.
diarrhea.
Headaches.
Rotor.
Fluid retention and high blood pressure.

Less common, frequently associated effects:
Ulcers of the esophagus.
Heart failure (with some species).
renal failure.
Bronchial constriction.

Effect on kidneys

These medications are usually effective, however, it is important to recognize that there is no drug that is completely safe without risk, and drugs in general should be used carefully; when used incorrectly, pain medications - painkillers - can cause major problems in the body, , Which is the worst damage, according to the National Kidney Foundation of America, up to 3 per cent to 5 per cent of new cases of chronic kidney failure may occur every year because of the excessive use of painkillers, which affected the functional construction of kidneys and safety on the way And reduce their blood supply.

Rules of use of painkillers

1. Do not use it (unless you have to).
2. Make sure to read the warning label before using any non-prescription painkillers.
3. Do not use over-the-counter pain relievers for more than 10 days or more than three days for fever.
4. If you have pain or fever for a longer period, you should visit your doctor.
5. Avoid using pain medications that contain a combination of ingredients, such as aspirin, acetaminophen and mixed caffeine in one tablet.
6. If you are taking analgesics, increase the amount of fluids you drink to 6 to 8 cups a day.
7. Do not take it for long periods, and do not advise others.

The creams and topical anti-inflammatory substances used directly in the pain site may have an effective ability to reduce and treat them, as well as have fewer side effects than tablets or capsules

German news agency

What are contraindications?

Children and adolescents infected with viral infection (with or without fever) should not take aspirin or products containing aspirin because of the risk of Ray syndrome.
Kidney patients.
Liver patients.
Known allergies to drugs, especially aspirin.
Ulcers in the stomach or an earlier history of ulcer bleeding.
Gastroesophageal reflux disease, also known as GERD.
Heart failure.
Asthma gets worse when taking aspirin.
Pregnancy in the third chapter.
History of stroke or heart attack.
If you are over 65 years old or older.
Any medication treated for any of the above.

What is the optimal alternative?

Because non-steroidal anti-inflammatory drugs can cause unpleasant side effects, alternatives are often recommended - firstly, and the main alternative to pain relief is paracetamol, which is available over the counter and is safe for most people, except for liver patients.

The creams, topical anti-inflammatory substances used directly in the pain area may be effective in reducing and treating them, and with fewer side effects than tablets or capsules, your doctor may also be able to recommend different medications and treatments depending on your situation. , Physical therapy may help some people who suffer from muscle or joint pain.

The use of painkillers, for long periods and in an unorganized way, is a healthy habit that is wrong, but small, in the eyes of many, but it then causes catastrophic consequences, which in some cases may lead to chronic, non-healing diseases, From the pharmacists and doctors - most of whom are devoid of human conscience - through the health organizations, and the drug, to raise awareness of the people of the dangers of excessive use of painkillers, reaching you dear reader, talk to your colleagues and your family, the danger of the subject, and participated in the article in your community, Life.