The Nanzhong Expressway is located in the core of the Guangdong-Hong Kong-Macao Greater Bay Area. The main line starts from the Nansha Port Expressway Xinken Interchange and ends at the Zhongjiang Expressway.

The bidding section contracted by China Railway Bridge Bureau is the project's pilot project, with a total length of 4.211 kilometers. The project department optimized the straight track into an arc track that fits the line shape of the main tower.