Yitzhak Yosef is one of the two most senior rabbis in Israel. He represents the Sephardic sect (Eastern Jews), while the other rabbi represents the Ashkenazi sect (Western Jews) He was famous for his intense hatred of Arabs and Palestinians and his racist statements towards them.

His father Ovadia Yosef was the founder and spiritual leader of the Shas movement, an extreme right-wing religious Israeli party. Yitzhak is married to Ruth, the daughter of Kabbalist Rahmim Attia.