Spanish researchers discover why some anti-cancer drugs sometimes don't work. Not only what is written in our DNA influences our chances of developing a tumor.
Everything that regulates the expression of our genome also has a lot to say in the risk of cancer. There are already drugs that act directly on these chemical marks that can make a certain gene 'turn on' or 'off' The persistence of certain tumor cells with different mutations is associated with little clinical benefit from epigenetic drugs, the researchers say.