New discoveries by Shanghai scientists bring new strategies for the treatment of tumors, organ damage and other diseases. Key enzyme of the cholesterol synthesis pathway can regulate the sensitivity of ferroptosis that is closely related to various diseases such as tumors.
Levels of the metabolite 7-dehydrocholesterol directly affect cellular sensitivity to ferroPTosis. In terms of organ damage treatment, the research team found that pharmacologically targeted inhibition of DHCR7 can effectively accumulate 7-DehydroCholesterol in the body.