We've all received a no when what we needed to hear was a yes. Some professions, in fact, are specially made to move between negatives until they find the yes.

For many is frustration, mutilated self-esteem and deep sense of failure. For others is simply a pitfall alien to their self, which must be overcome whether it costs a lot or little. Why do some become a Titanic where others choose to persist on their Everest? The four successful professionals we gathered for this report know well what the noes of life taste like.