Thyroid eye disease is the most common orbital disease. It is an autoimmune disease that can occur at any age.

The most obvious symptom is exophthalmos. In addition to protruding eyeballs, the whites of the patient's upper and lower eyes are often exposed. Patients may also have swollen eyelids, inability to open their eyes, red eyes, watery eyes, fear of light, or inability to look straight ahead with two black eyeballs at the same time, seeing one object as two.