Abdul Qader Al-Husseini was born in Istanbul in 1908 to a wealthy family close to the Ottoman court. He was considered the first to start the Great Palestinian Revolution in 1936.

He joined the battalion of the famous Syrian mujahid Saeed al-Aas, and fought several battles alongside him. In 1938 he was an infiltrator of the armed revolution in Palestine and participated in many of the battles against the British forces. On April 8, 1948, while fighting the battle to liberate the city of Qastal, he was martyred.