The meeting in Manchester at the Etihad Stadium ended with a score of 4:3 in favor of the hosts.
Bernardo Silva scored the winning goal.
Recall that the second leg will be held in Madrid at the Santiago Bernabeu Stadium on May 4.
The start is at 22:00 Moscow time.
Liverpool will face Villarreal in the second semi-final of the tournament.
The meeting will take place on April 27 at 22:00 Moscow time.
Previously, the match between Manchester City and Real Madrid repeated the performance record for the semi-finals of the Champions League.