Edsbyn opened the scoring after just under three minutes when Mattias Hammarströn thundered the ball into the net.
The home team was clearly better, but it still took a while before the break before they got a dividend again.
Martin Frid put 2-0 and then Oscar Wikblad made it 3-0 on penalties after Sirius goalkeeper Anton Andersson fouled him.
The Russian Vadim Arkhipkin extended in the second half and then Frid made his second for the evening after a corner.
Arvid Tapper and Jerker Ortman reduced for the Uppsala team, but there was never any nerve.
- In general, we give what we have, but it's a bit like cod today, says Sirius coach Oscar Robertson in Aftonbladet's broadcast.
Edsbyn, who finished third in the basic series, will now face series runner-up AIK in the semifinals.
In the second semifinal, Villa Lidköping and Västerås will meet.