China News Service, Beijing, February 2 (Reporter Sun Zifa) As we all know, pregnancy in ten months is an important and challenging process for women. In order to nurture the embryo/fetus in the uterus, various tissues and organs in the pregnant woman undergo adaptive changes. However, the specific changes at the molecular level and how the interactions between tissues and organs maintain pregnancy (pregnancy adaptation) remain unclear.
Based on this, multiple scientific research teams in China conducted collaborative research and constructed a metabolome map of a total of 273 samples of 23 tissues and organs of the primate model cynomolgus monkey during non-pregnancy and different stages of pregnancy, revealing the pregnancy of cynomolgus monkey. Dynamic evolution of metabolic networks, metabolic pathway adaptation and key adaptive metabolites in various tissues and organs during this period.
Design diagram of grouping and sample collection for this study. Photo courtesy of the Institute of Zoology, Chinese Academy of Sciences
This important research paper revealing the metabolic adaptation of primate multiple tissues and organs during pregnancy was jointly sponsored by the Institute of Zoology of the Chinese Academy of Sciences/Beijing Institute of Stem Cells and Regenerative Medicine Huang Shiqiang’s team, Wang Hongmei’s team, Li Wei’s team, and the Affiliated Women and Children’s Hospital of Chongqing Medical University Qi Hongbo's team jointly completed the work and published it online in the internationally renowned academic journal "Cell" in the early morning of February 2, Beijing time. It is important for understanding the normal adaptive changes of multiple maternal tissues and organs during pregnancy and revealing the mechanism of disease caused by abnormal pregnancy adaptation. It is also of great significance to fundamentally improve the health of mothers and infants.
The research team said that non-human primate monkeys are highly similar to humans in terms of physiology, reproductive characteristics and pregnancy cycles, and are the most ideal animal model for studying the pregnancy adaptation of primate maternal tissues and organs.
In order to systematically understand the metabolic adaptation of various maternal tissues and organs during primate pregnancy, the research team analyzed the untargeted metabolome of a total of 273 samples of 23 tissues and organs in cynomolgus monkeys during non-pregnancy, early pregnancy, mid-pregnancy and late pregnancy. , it was found that the metabolome of each tissue and organ has unique change patterns during non-pregnancy and different stages of pregnancy.
Subsequently, the research team conducted correlation analysis, metabolic pathway and metabolite analysis on the metabolome data of 23 tissues and organs during non-pregnancy and early, middle and late pregnancy. The results showed that primate mothers experience huge metabolic disturbances during pregnancy. and challenges, metabolic reprogramming occurs in a variety of tissues and organs. On this basis, the research team further studied the potential functions of key differential metabolites in cell growth or differentiation of tissues and organs. In order to further explore the adaptive changes and regulatory mechanisms of differential metabolites on important maternal tissues and organs during human pregnancy, Important experimental evidence is provided.
Summary diagram of the overall idea of this research. Photo courtesy of the Institute of Zoology, Chinese Academy of Sciences
The research team stated that in order to verify the potential translatability of the cynomolgus monkey metabolome data to humans, they also compared the blood metabolome data of pregnant cynomolgus monkeys with the published blood metabolome data of human pregnant women. The results showed that the blood metabolome of human pregnant women during pregnancy was Most of the metabolites that were up-regulated or down-regulated showed similar trends in the blood data of pregnant cynomolgus monkeys, which preliminarily confirmed that the cynomolgus monkey metabolome data obtained in this study has potential clinical application value and is also a better way to better It lays an important foundation for understanding how primate mothers adapt to the metabolic challenges of pregnancy. (over)