Portugal's Rui Costa sprinted past Italian Andrea Bagioli to take second place.
David Gaudu finished fourth.
Perez, a 31-year-old puncher, took advantage of the excess number of Cofidis in the leading group 50 kilometers from the finish to go out alone in the lead, then produced a good effort to win the second race of his career, a year after his success in the Classic Loire-Atlantique.
Prior to those two titles, Perez had picked up four stage wins in secondary rounds.
From the first kilometres, several curbs made a first selection among the contenders for victory, immediately dismissing the Australian Jai Hindley and the Colombian Sergio Higuita.
Winner the day before of the Ardèche Classic, which makes up, with the race of the day, the Boucles Drôme-Ardèche, Julian Alaphilippe this time rode for his Italian teammate Andrea Bagioli.
The former double world champion even got up in the last ten kilometers.
© 2023 AFP