Former Bavarian State President Barbara Stamm died in her hometown of Würzburg on Wednesday morning.
The state parliament announced this on the Twitter internet service, citing the family.
She died after a long illness.
Stamm was 77 years old.
She was born in October 1944 in Bad Mergentheim.
Stamm headed the Bavarian state parliament from 2008 to 2018.
She was the first woman to hold this office.
She was a member of the state parliament for a total of 42 years and was also a member of the state government for more than 13 years, including as state secretary and minister and from 1998 to 2001 as deputy prime minister.
In 2009 she made her breast cancer diagnosis public.
"I am deeply affected by the news of the death of my predecessor," said the incumbent President of the State Parliament Ilse Aigner (CSU).
"With Barbara Stamm, we are losing a politician who is popular and highly esteemed across all party lines, who for decades worked primarily for the poorer and weaker in our society and gave them a voice."
As the first woman to head the Bavarian state parliament, she “earned great respect and a high reputation.
With her, we are losing a great role model for women in politics, a passionate fighter for the weak in society and a convinced democrat.”