Russian Foreign Minister Sergei Lavrov has accused Western countries of a "grotesque" fear of Russia.
"Official Russophobia in the West is unprecedented, the scale is grotesque," Lavrov said at the UN general debate in New York on Saturday.
The states did not shy away from "destroying Russia".
Lavrov's speech had been eagerly awaited against the background of Russia's war of aggression against Ukraine.
The UN general debate this year is dominated by the Ukraine war, which escalated further this week due to the partial Russian mobilization.
The Russian Foreign Minister had already given a speech to the UN Security Council on Thursday, making serious allegations against Ukraine - and left the room after his speech.
Lavrov defends referendums
Lavrov accused the US on Saturday of trying to "turn the whole world into their backyard."
"After declaring itself victorious in the Cold War, Washington has almost risen to become an emissary of God on earth, with no obligations other than the sacred right to act with impunity anywhere, anytime," he said.
He also said the US government would be "playing with fire" on the Taiwan issue.
He also defended the so-called referendums in four Russian-controlled areas in Ukraine for annexation by Russia.
Only people claimed the land "on which their ancestors have lived for hundreds of years," Lavrov said.
"The West is now freaking out about the referendums."
Kyiv and its western allies have criticized the referendums in the separatist regions of Donetsk and Luhansk and in the Kherson and Zaporizhia regions as sham referendums.
A connection of the four Ukrainian regions to Russia as a result of the "referendums" is condemned by the West as illegal.
US President Joe Biden threatened Russia with tough sanctions in the event of annexations on Friday.