Seven years have passed since the fast food giant entered the country, but the business did not take off.
The Milan-based company ePizza, which was a franchisee for Dominos in Italy, was forced to file for bankruptcy in April this year, writes the newspaper Milano Today.
At the end of July, work ceased in all restaurants and now the chain has formally closed again.
Local pizzerias
According to the company itself, it was apps that offer home delivery from restaurants that represented the nail in the coffin.
During the last two years of the pandemic, they faced greatly increased competition from local pizzerias, which increasingly began to use delivery companies such as Glovo, Just Eat and Deliveroo, writes CNN.
The company's problems continued as pandemic restrictions eased and consumers increasingly returned to sit-down restaurants.
Domino's original marketing plan was to create a large-scale home delivery business, which did not exist in Italy when the company first established itself in the country.
A total of 33 stores were opened, while the actual goal was 800, writes the Washington Post.
"Don't like pineapple"
The announcement that the company is being forced to close in Italy has given rise to some banter - both on newspaper pages and in social media.
The Italian newspaper Il Messagero, for example, used the headline "Italians don't like pineapple pizza" and writes, among other things, that menus with "Pepperoni Passion" and "Hawaiana" did not impress the Italian puritans.
One user on Twitter compared Domino's establishment plan in Italy to trying to sell snow at the North Pole, while other users drew attention to the fact that the chain's pizzas were often more expensive than local pizzerias.