The highly anticipated neurosurgeon-turned-sorcerer sequel, which sees Marvel hero Benedict Cumberbatch explore parallel worlds, grossed $187 million in its first three days in theaters last week.
Internationally, the film has grossed $396 million since its release.
A distant second was the animated film "The Bad Guys," outlaw animals that try to become nice, with just $6.9 million from Friday to Sunday.
Like last week, the blue hedgehog from "Sonic 2" completes the podium in third place with $4.6 million.
New to theaters, "Firestarter," a half-crime, half-fantasy film based on a novel by genre master Stephan King, got off to a disappointing start with a fourth-place finish and just $3.8 million in revenue.
Zac Efron and Sydney Lemmon play the parents of Ryan Kiera Armstrong, an 11-year-old girl with extraordinary pyrokinesis abilities who is being hunted down by a mysterious government agency that would like to use her fire-triggering abilities to create a weapon of mass destruction.
The film was slammed by critics and garnered just 12% positive reviews on Rotten Tomatoes, which aggregates ratings from different sources.
It's quite the opposite for "Everything Everywhere All at Once".
With 96% of favorable opinions, this feature film with Michelle Yeoh also traveling to the absurd in the universe of parallel worlds, completes the top 5 with 3.3 million dollars in revenue for its 8th week in dark rooms.
Here is the rest of the Top 10:
6. "Fantastic Beasts: Dumbledore's Secrets ($2.4 million)
7. "The Secret of the Lost City" (1.7 million)
8. "The Northman" (1.7 million)
9. "Family Camp" (1.4 million)
10. "Solid Gold Talent" (1.1 million)
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