China News Service, Shenzhen, March 4th (Reporter Zheng Xiaohong) The reporter learned from the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences (referred to as: Shenzhen Institute of Advanced Technology) on the 4th that a new research result published in "Nature" on the 3rd showed that follicle stimulation The increase in hormone levels is an important reason why women are more likely to suffer from Alzheimer's disease than men.
This discovery was made by the research team of Ye Keqiang (former tenured professor of Emory University), chair professor of the School of Life and Health of Shenzhen University of Technology, Chinese Academy of Sciences (tentative name, referred to as Shenzhen University of Science and Technology) and the Institute of Brain Cognition and Brain Diseases, Shenzhen Advanced Institute of Chinese Academy of Sciences. Experiments were carried out from four different angles and ways to verify its accuracy.
"This important discovery not only provides a new cause and mechanism for why women are more susceptible to Alzheimer's disease, but also provides a new molecular target for early clinical screening and intervention for Alzheimer's disease." Tongji, Huazhong University of Science and Technology Jianzhi Wang, a professor in the Department of Pathophysiology at the School of Medicine, commented.
Keqiang Ye's team is committed to the research on the pathogenesis, early diagnosis and drug development of neurodegenerative diseases.
On the basis of systematically summarizing the achievements of the team's hundreds of cutting-edge academic papers, he proposed the research theory that "there is a 'C/EBPβ/AEP neural signaling pathway' in the brain, and the activation of this pathway is the core driving factor leading to neurodegenerative diseases". .
Based on this conclusion, the research team studied the hormones whose concentrations vary sharply in women before and after menopause, and found that among more than ten core hormones with important changes, follicle-stimulating hormone is the factor that makes women more susceptible to Alzheimer's disease. important causative factors.
Studies have shown that after menopause, the follicle-stimulating hormone content in the body of women will increase sharply to 10 times to dozens of times, while the follicle-stimulating hormone in elderly men of the same age only increases by 2 to 3 times.
When the sharply increased follicle-stimulating hormone binds to receptors on the surface of neurons in the brain, it activates the C/EBPβ/AEP pathway in the brain, leading to Alzheimer's disease.
I can't remember what I just said, I can't remember what I just did, I can't recognize the people around me... Alzheimer's disease is one of the most difficult diseases to cure in the world, and it is called "the eraser in the mind" .
According to reports, there are at least 50 million Alzheimer's patients worldwide.
Epidemiological surveys have shown that the number of women with Alzheimer's disease is twice as high as that of men, but the cause of this phenomenon has previously been unclear.
Faced with a higher risk, how can women reduce the incidence of Alzheimer's disease?
In this regard, Ye Keqiang, the corresponding author of the paper, said that a balanced diet, maintaining an optimistic attitude, avoiding excessive stress, exercising reasonably, and ensuring adequate sleep time and quality can help reduce inflammation in the body and appropriately delay the arrival of menopause. To a certain extent The onset of the disease can be delayed.
It is understood that the research team's specific antibodies against follicle-stimulating hormone are under preclinical research, with a view to bringing new treatment strategies for Alzheimer's disease.
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