The "Dogues" went to win in Montpellier (1-0) on Saturday, to revive after their rout at home against Paris SG (5-1), a week earlier.
Tenth in the standings, they need to chain a second consecutive success to return to Nice, third at seven points.
A good result would also allow Lille to gain pace before challenging Chelsea on Tuesday in London, in a round of 16 first leg of the Champions League, which they approach as outsiders.
Against Real Madrid (1-0) on Tuesday, Paris SG showed Losc how to go about it in a major European meeting.
Before the return leg at the Santiago-Bernabeu stadium on March 9, Kylian Mbappé's teammates have three weeks to refine the automation.
It starts in Nantes on Saturday (9:00 p.m.), where Neymar, back from injury, could experience his first tenure since the end of November.
Ranking of Ligue 1 football Vincent LEFAI AFP
Earlier (5:00 p.m.), Lyon went to Lens, an important match for OL (7th), at one of their competitors (8th) at the top of the table.
At the very bottom, the red lantern Bordeaux receives Monaco on Sunday (5:05 p.m.).
Marseille, dolphin of PSG, concludes the weekend against Clermont-Ferrand.
Program of the 25th day of Ligue 1
(21h00) Lille - Metz
(5:00 p.m.) Lens - Lyon
(21h00) Nantes - Paris SG
(1:00 p.m.) Nice - Angers
(3:00 p.m.) Lorient - Montpellier
Reims - Brest
Rennes - Troyes
Saint Etienne - Strasbourg
(5:05 p.m.) Bordeaux - Monaco
(8:45 p.m.) Marseilles - Clermont
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