China News Service, Beijing, December 9th (Reporter Sun Zifa) The internationally renowned academic journal "Nature" recently published a neuroscience research paper. Through a mouse study, researchers found that exercise can improve those that have a protective effect on the brain. Anti-inflammatory factor levels.
The study showed that if these anti-inflammatory factors are transferred to mice that do not exercise, they can also improve their learning and memory; a small group of cognitively impaired patients will have these anti-inflammatory factors in their bodies after exercising for 6 months. Increased.
The results of this study provide new insights into the mechanism of how physical exercise is beneficial to the brain.
According to reports, although the benefits of exercise on the brain and cognitive functions are well known, the mechanism behind it has yet to be elucidated.
In order to determine whether exercise can increase the level of factors that are beneficial to brain function and health in the plasma, the corresponding author of the paper, Tony Wyss-Coray of Stanford University School of Medicine, and his colleagues never exercise mice and use running Plasma was collected from the 28-day-old mice, and the plasma was injected into the immobile young mice.
Their study found that mice injected with running mouse plasma had a significant increase in hippocampal cell proliferation and survival, which was similar to the direct effects of running observed in exercise mice.
Mice injected with plasma from running mice also improved their learning and memory in the environment and space.
The author of the paper performed a proteomic analysis of the plasma and found that specific factors, such as clusterin, play a key role in the anti-inflammatory effects of exercise.
Intravenous injection of cluster protein showed anti-inflammatory effects in both acute brain inflammation mouse models and Alzheimer's disease mouse models.
They also found that after 6 months of physical exercise intervention, the cluster protein levels in the plasma of 20 patients with mild cognitive impairment increased.
The results of this study indicate that there may be a transferable anti-inflammatory "motor factor" in plasma that is beneficial to the brain, which can point new directions for the development of treatments for diseases such as Alzheimer's disease.
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